A true global success story!

Scaling up Genetic Signatures’ PCR-based test kit production
with an X-TubeProcessor®_Smart from HTI Automation

When we started our conversation with Genetic Signatures back in 2020, they were looking for a solution to support them to upscale their production capacity to meet the growing demand for their EasyScreenTM assay for COVID-19 PCR testing. Whilst Genetic Signatures’ molecular diagnostic test kits are manufactured in Sydney, Australia, they are a global company and therefore, were open to partnering with HTI due to our high-quality instrumentation, and timely service and support. We have developed an amazing partnership over the past 1.5 years, and as Genetic Signatures further expands their global customer base, we continue to support their growing production requirements with the implementation of two X-TubeProcessor®_Smart units.

Big thanks to Brett Clark, for the interview below, from April 2022:

HTI: What is your daily production routine and which challenges are you facing in terms of capacities, timelines and quality?
Brett: Being a flexible and customer-focused company has meant that we have implemented new processes and workflows in the last few years. Having the ability to rapidly set up and scale-up processes in Production have allowed us to maintain product supply throughout the pandemic.

HTI: Which challenges did especially Covid bring?
Brett: The sudden need to have equipment that would allow for us to scale-up and automate new procedures was difficult in the Covid climate. Due to global logistics issues and border constraints, the set up and implementation of equipment was hindered.

Brett Clark, Production Manager at Genetic Signatures

The ease of use and ability to easily install the instrument are key advantages to this system. HTI have made the software and platform very user friendly. This makes it a very simple instrument to train new users on the daily operation.

HTI: Which solution have you been looking for and why did you finally decide for the HTI?
Brett: We needed instruments that could be easily integrated into our routine manufacturing schedule. HTI was able to provide a workflow that suited our processes with minimal footprint. The service and information provided by HTI during the decision-making process made it very easy to select them as the preferred supplier.

HTI: How can the HTI device help you with the above named?
Brett: The X-TubeProcessors are able to achieve the desired daily targets within a footprint that was easily integrated into our site. They were easy to install and validate. This allowed for us to be utilising their capabilities in a short timeframe. Day-to-day the ease of running these instruments and the minimal downtime has assisted in fulfilling our customer’s needs.

HTI: How does the cooperation “across the ocean” work?
Brett: Working with HTI, on opposing time zones has never been an issue. The initial installs and training were performed over video calls at times that were within our usual daily routine. Moving forward, all services and technical support questions were answered promptly. The information provided at each stage by the technical support team has been highly beneficial in resolving any issues and have now created an extensive troubleshooting training module for staff using the instruments.

HTI: Are there special advantages of the system?
Brett: The ease of use and ability to easily install the instrument are key advantages to this system. HTI have made the software and platform very user friendly. This makes it a very simple instrument to train new users on the daily operation. Additionally, the daily output of the instrument for its small footprint is highly beneficial when space is critical!

HTI: Is there something which you would improve on the device?
Brett: As the instruments are very easy to operate there are minimal changes I would recommend. Minor software changes that would be beneficial would be to have all sample details retained for specific programs (such as liquid density). In terms of the instrument deck, there are some small areas which are difficult to clean if needed. However, the newer X-TubeProcessor model has some beneficial upgrades to the software and includes a simplified deck layout which assists in routine cleaning and maintenance.

Genetic Signatures is an established, global molecular diagnostics company, driving improved patient outcomes by providing flexible PCR-based test kits, under the EasyScreenTM brand, to support the detection of over 100 pathogens across a large range of infectious diseases. These test kits are underpinned by Genetic Signatures’ unique 3baseTM technology, which improves PCR efficiency and reduces the genetic complexity of detecting pathogens. In addition, the flexible and automated workflow supports simplified detection of a large number of pathogens in a single sample, known as syndromic testing, whilst preserving throughput.

Genetic Signatures’ diagnostic solutions support a growing international customer base of leading hospitals and pathology laboratories to increase laboratory workflow, reduce time to test result and improve patient management.




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